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    No tall dose–impulse inverse association try observed between calcium intake and danger of event colorectal adenoma (Desk dos)

    No tall dose–impulse inverse association try observed between calcium intake and danger of event colorectal adenoma (Desk dos)

    Experience colorectal adenoma

    Compared with controls without polyps, incident adenoma cases were more likely to be male, smokers, physically inactive, have higher body mass index, and have higher intake of energy, but had lower intakes of calcium, magnesium and vitamin D (Table 1). However, intakes of calcium between 1200 mg and 1600 mg per day were associated with a significantly reduced risk of incident adenoma with an OR of 0.82 (95% confidence intervals (CI): 0.68–0.97) when compared with calcium intake between 600 and 1200 mg per day (referent group). When analyses were limited to incident advanced and/or synchronous adenomas, the inverse pattern of associations was found with a corresponding OR of 0.71 (95% CIs: 0.52–0.96) for calcium intake between 1200 and 1600 mg. When these analyses were stratified by the Ca:Mg ratio, the dose–response between calcium intake and advanced and/or synchronous adenoma were only observed in participants with a Ca:Mg ratio between 1.7 and 2.5 (P-trend, 0.05). The number of cases in the Ca:Mg ratio < 1.7 strata was too small to make meaningful statistical inference. There was no statistically significant communications between calcium and the Ca:Mg ratio (P-interaction: 0.11).

    Metachronous (recurrent) adenoma

    In contrast to professionals in place of fabswingers taktikleri metachronous adenoma, metachronous adenoma circumstances was in fact together with prone to become male and you can overweight, and possess highest complete opportunity consumption but lower calcium supplements intake (Table step 1). Metachronous adenoma cases have been less likely to want to feel white in order to keeps family history regarding CRC.

    We didn’t observe any mathematically tall relationships ranging from calcium supplements consumption and you can metachronous adenoma (Dining table step three).